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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Regulation of bacterial transcription by alternative sigma factors.
 Benda, Martin ; Krásný, Libor (advisor) ; Roučová, Kristina (referee)
An important feature of bacteria is their ability to respond to various environmental conditions by regulation of transcription. This thesis is focused on regulation of transcription initiation by different sigma factors. Sigma factor is a specific subunit of RNA polymerase, which ensures correct recognition of promotor sequences. During exponential growth phase under ideal conditions, the cell transcribes most of the genes under the control of the so-called housekeeping sigma factor. In the transition to stationary phase, during sporulation or upon exposure to different stresses, many genes are activated and transcribed under the control of alternative sigma factors. This work presents a list of these alternative sigma factors of Bacillus subtilis, focusing on conditions under which the individual sigma factor is used, methods of activation and repression of these factors and on regulons controled by these sigma factors.
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